Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells
نویسندگان
چکیده
منابع مشابه
Gene targeting in human pluripotent cells.
Mouse embryonic stem cells (mESCs) have the ability to differentiate into any cell type and can generate chimeric mice when transplanted into a host blastocyst. This remarkable potential, together with the development of robust gene targeting strategies in mESCs, were essential for establishing the mouse as the most widely used model organism in biomedical research. Recent advances have allowed...
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Multiple sclerosis (MS) is an autoimmune disease which affects myelin in the central nervous system (CNS) and leads to serious disability. Currently available treatments for MS mainly suppress the immune system. Regenerative medicine-based approaches attempt to increase myelin repair by targeting endogenous progenitors or transplanting stem cells or their derivatives. Fingolimod exerts anti-inf...
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ژورنال
عنوان ژورنال: STEM CELLS Translational Medicine
سال: 2015
ISSN: 2157-6564
DOI: 10.5966/sctm.2015-0050